Protein purification cost reduction9/17/2023 ![]() ![]() ![]() One possible approach to this challenge is to use more efficient resins, and high-capacity protein A resins seem promising. Only after that may manufacturers take full advantage of high titers and large bioreactor volumes. Large feed streams also require higher downstream capacities and increase demands on labor and plant equipment, which of course increases the investment.ĭebottlenecking the downstream platforms is a current concern in regard to both process capacity and cost. ![]() Protein A ligands for chromatography need to be alkaline stable, highly discriminating, with low ligand leaching levels, which requires substantial effort in development of these affinity media. Traditionally, protein A resins have a comparably high share among the costs of consumables in MAb processing. Membrane and chromatography resin savings are more important for MAb processes than ever before, with highly productive cell cultures generating large volumes of process fluid to purify ( 2). Consequently, cost pressures are now passed on to downstream process groups. The need for more economic processes has been addressed by increasing MAb titers in fermentation and aiming toward greater bioreactor volumes to increase productivity. GRAPHIC STOCK (Monoclonal antibody (MAb) production has adopted an accepted technology platform for downstream processing ( 1). ![]()
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